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Thus, these two studies sought to examine the brains of transgender individuals to figure out if their brains better resembled their assigned or chosen sex.

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As they matured, many had a clear sense that they were male. During normal feminization, sufficient estrogen is present in the fetal environment. Responding to this question can be more precise by consideration of cultural neuroscience concepts, particularly a culture—behavior—brain CBB model and the interactions between behavior, culture and brain.

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